摘要
目的探讨血浆N-末端脑钠肽检测在慢性阻塞性肺疾病(COPD)患者中的临床意义。方法收集2007年5月～2009年12月我院内科住院收治的COPD急性发作患者75例,另选择同期我院门诊健康体检者40名为对照组。采用酶联免疫吸附法(ELISA)检测两组血浆N-末端脑钠肽(NT-proBNP)浓度。结果 COPD组患者血清NT-proBNP浓度明显高于正常对照组(P<0.01)。轻度、中度、重度低氧血症COPD组患者血清NT-proBNP浓度比较,差异有显著性(P<0.01),且COPD患者血清NT-proBNP浓度随着缺氧程度的升高而增高,血清NT-proBNP浓度与PaO2呈负相关(r=-0.769,P<0.01)。结论血清NT-proBNP浓度在COPD的诊断及疾病严重度的评价中可能具有较好的临床价值。
Objective To investigate the changes of plasma significance in chronic obstructive pulmonary disease （COPD）. N-terminal probrain natriuretie peptide （NT-proBNP） and its clinical Methods We selected 75 cases of COPD and 40 normal people as control group. The plasma NT-proBNP level was measured by ELISA. Results The plasma NT-proBNP level in COPD was much higher than that in the control group （P〈0.01）. The plasma NT-proBNP level in COPD was significantly increased with different PaO2 （P〈0.01）. The plasma NT-proBNP level had a significantly negative correlation with Pa02 （t=-0.769,P〈0.01）. Conclusion The plasma NT-proBNP level in COPD is of great value in the diagnosis and evaluation of the severity of the disease.
出处
《中国现代医生》
2010年第34期4-5,共2页
China Modern Doctor
