埃索美拉唑联合伊托必利治疗反流性食管炎的疗效观察

Esomeprazole Combined with Itopride Hydrochloride for Reflux Esophagitis:Observation of Therapeutic Efficacy

目的观察埃索美拉唑联合伊托必利治疗反流性食管炎的有效性和安全性,旨在探索反流性食管炎的最佳治疗方案。方法 80例患者随机分为治疗组和对照组各40例,治疗组给予埃索美拉唑20mg,每日2次,伊托必利片50mg,每日3次,对照组给予埃索美拉唑片20mg,每日2次,疗程8周。结果反流性食管炎临床疗效表现,治疗组有效率95%,对照组有效率70%,两组比较差异有统计学意义(P<0.01),反流性食管炎胃镜表现治疗组有效率90%,对照组有效率67.5%,两组比较差异有统计学意义(P<0.01)。结论埃索美拉唑联合伊托必利治疗反流性食管炎治疗率高、症状缓解快、不良反应小,值得临床推广应用。

Objective To observe the clinical efficacy and safety of Esomeprazole and combined with Itopride hydrochloride in the treatment of reflux esophagitis in an attempt to explore the optimal treatment of reflux esophagitis. Methods Eighty cases-were randomly divided into two groups： treatment group and control group with 40 cases in each. The treatment group was treated with Esomeprazole 20 mg, Bid and hopride hydrochloride 50 mg,Tid for 8 weeks, while the control group was treated with Esomeprazole 20 mg, Bid for 8 weeks. Results The clinical manifestation of reflux esophagitis after treatment showed the effective rate of the treatment group was 95% , and that of the control group was 70%, with a significant difference between the two groups （P〈0.01）. The endoscopic observation of reflux esophagitis showed the effective rate of the treatment group was 90% and that of the control group was 67.5%, with a significant difference between the two groups （P〈0.01）. Conclusion Esomeprazole combined with Itopride hydrochloride has a significant therapeutic effect on reflux esophagitis, and can rapidly relieve its symptoms and decrease the adverse effect rate, worth clinical popularization and application.