内脏脂肪素、脂联素、瘦素与肥胖、2型糖尿病的相关性研究

Study on the relationship of plasma visfatin,adiponectin and leptin with obesity and type 2 diabetes mellitus

目的探讨内脏脂肪素(Visfatin)、脂联素(APN)、瘦素水平与肥胖及2型糖尿病(T2DM)的关系。方法 85例研究对象分为糖耐量正常(NGT)组和T2DM组。根据BMI,NGT组再分为正常对照(NC)组和单纯肥胖(S-Ob)组,T2DM组再分为糖尿病非肥胖(T2DM NOb)组和糖尿病肥胖(T2DMOb)组,测定并分析各组Visfatin、APN、瘦素水平并对影响因素进行相关分析。结果 (1)四组间Visfatin、APN、瘦素、FIns、HDL-C差异均有统计学意义(P<0.05或P<0.01)。(2)85例研究对象分为肥胖组及正常体重对照组,两组间Visfatin、瘦素、FIns、HDL-C、尿酸差异有统计学意义(P<0.05或P<0.01)。(3)WHR是Visfatin的独立影响因素(r=0.519,P<0.05)。结论 Visfatin可能在肥胖和T2DM的发生和发展中有一定作用。

Objective To study the relationship of visfatin, adiponectin and leptin levels with obesity and diabetes. Methods 85 cases of subjects included normal glucose tolerance （NGT） group （n =20）, type 2 diabetes mellitus （T2DM） group （n=43） and simple obesity group （S-Ob,n=22）. T2DM had subgroups of T2DM-Ob （n = 22） and T2DM without Ob （n = 21）. Visfatin, adiponectin and leptin were determined. Results （1） Among the four groups, the differences in visfatin, adiponectin, leptin, fasting insulin and high-density lipoprotein cholesterol （HDL-C） were statistically significant（P〈0. 05, or P〈0.01）. （2） The differences in visfatin, leptin, fasting insulin, HDL-C,cholesterol and uric acid（P〈0.05, or P〈0. 01）were significant between obesity and non-obesity. （3） Waist-to-hip ratio was an independent influencing factors for visfatin. （r=0. 519, P〈0. 05）. Conclusion Visfatin may play a role in the occurrence and development of obesity and DM.