尿单核细胞趋化蛋白1和尿视黄醇结合蛋白与糖尿病肾病的关系

Relationship of urinary monocyte chemoattractant protein-1 and urinary retinol binding protein with diabetic nephropathy

目的探讨尿单核细胞趋化蛋白1(MCP-1)、尿视黄醇结合蛋白(RBP)在糖尿病肾病(DN)中的作用及关系。方法对90例糖尿病患者按尿白蛋白排泄率(UAER)分为正常白蛋白尿(NA)组、微量白蛋白尿(MA)组、大量白蛋白尿(LA)组共3组,分别测定尿MCP-1与尿RBP,并与30名健康对照(NC)组比较。结果 NC、NA、MA、LA组间的尿MCP-1及尿RBP水平逐渐升高(P<0.05或P<0.01);尿MCP-1水平与尿RBP(P<0.01)、UAER(P<0.01)均呈正相关;尿RBP与UAER呈正相关(P<0.01)。结论糖尿病肾病患者随着尿蛋白的升高,尿MCP-1和尿RBP也逐渐升高。

Objective To study the changes of the urinary level of monoeyte chemoattractant protein-1 （MCP1） and retinol binding protein（RBP） and their relationship with diabetic nephropathy. Methods According to urinary albumin excretion rate （UAER）, 90 diabetic patients were divided into three subgroups ： normo-albuminuria（NA）, micro alhuminuria（MA） and clinical alhuminuria （LA）. Urinary levels of MCP-1 and RBP were determined respectively,and compared with those of 30 normal controls（NC）. Results In type 2 diabetic patients, the levels of urinary MCP-1 and RBP in LA group（476.38 ± 86.32,58.42± 25.33） were significantly higher than those in NC group（79.22±7.30,10.84±7. 17;all P〈0.01）and NA group （147.35±49.62,20. 18±9. 31;all P.〈0.01）and MA group （321.61±65. 18,47.67±18.65;all P 〈0.05）. The levels of urinary MCP-1 and RBP were significantly higher in MA than group in NC group（P 〈0.01 ）and in NA group（P〈0.01）. The levels of urinary MCP-I and RBP in NA group were significantly higher than in NC group（P〈0.01 or P〈0. 05）. Urinary MCP-1 correlated positively with urinary RBP （r =0. 837,P〈0.01） and UAER（r= 0. 891 ,P〈0.01）. Urinary RBP correlated positively with UAER（r= 0. 903,P〈0.01）. Conclusions The urinary MCP-1 and RBP are gradually increased along with UAER increment in patients with diabetic nephropathy.