不同年龄2型糖尿病患者胰岛素泵基础率的特点

The distribution characteristics of insulin pump basal rate in type 2 diabetic patients at different ages

目的探讨不同年龄段2型糖尿病患者应用胰岛素泵基础率分布的特点。方法 152例病程大于1年的糖尿病患者分为青年组(<40岁)、中年组(40～60岁)、老年组(>60岁)共3组。分别给与胰岛素泵强化治疗,血糖控制平稳后,将基础率分为20:00～3:00、3:00～8:00、8:00～16:00、16:00～20:00共4段,计算每段中每小时平均基础率占全天总基础率的百分比并进行组间比较。结果中年组3:00～8:00基础率相比最高(P<0.05),老年组20:00～3:00基础率占全天基础率比例最小(P<0.05)。结论不同年龄段基础胰岛素分布不同,中年组黎明需要基础率较高,而老年组夜间需要胰岛素比例相较减少。

Objective To study the distribution characteristics of insulin pump basal rate in type 2 diabetes patients at different ages. Methods 152 type 2 diabetic patients diagnosed for more than 1 year were assigned into three groups： youth group（less than 40 years old）, middle age group（40-60 years old）, older age group（more than 60 years old）. All patients were treated with insulin pump. After stable blood glucose control, insulin pump basal rate was divided into 4 parts： 20：00 3：00, 3：00 8：00, 8：00-16：00, 16：00-20：00, hourly basal rate in average of every part was calculated, its percentage of the entire day basal rate was compared among different groups. Results 3：00-8：00 basal rate in middle age group was more than in other two groups（P〈0. 05）. 20：00-3：00 basal rate in older age group was less than in other two groups（P〈0. 05）. Conclusion Insulin pump basal rate is different in different ages, more basal insulin is needed in middle age group, less basal insulin is needed in older age group in the middle of the night.