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肝X受体与胰岛素抵抗:机制与临床意义

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摘要 胰岛素抵抗(IR)是2型糖尿病(T2DM)发病机制之一,而IR的发生机制尚未完全阐明。肝X受体(LXRs)通过调节多种靶基因的转录,在糖脂代谢中起重要作用。LXRs可抑制肝糖异生,降低胆固醇,调节炎症因子,影响糖皮质激素的活性,提高外周组织对葡萄糖的摄取。LXRs的功能紊乱可导致IR的发生。本文主要探讨LXRs及其激动剂与IR关系。
作者 尹洪涛 陈秋
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2010年第12期952-954,共3页 Chinese Journal of Diabetes
基金 四川省重大攻关项目(2006Z09-046)
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参考文献15

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