山苦瓜的抗癌活性成分

Studies on the Anti-cancer Active Constituents of Yunnan Momordica (Momordica dioica)

对葫芦科植物山苦瓜 Ｍｏｍｏｒｉｄｉｃａ ｄｉｏｉｃａ干燥块根的浸膏进行了分离、提纯，用Ｌ_(１２１０)、ＣＣＥＲ－ＣＥＭ、ＬＳ１７４Ｔ癌细胞对其成分进行了体外筛选，５个化合物具有抗癌活性，经光谱鉴定，它们是拜俄尼酸（Ⅷ）、雪胆甲素（ⅩⅠ）、α－菠甾醇－３－Ｏ－β－Ｄ－吡喃葡萄糖苷、丝石竹皂苷元（Ⅴ）及常春藤皂苷元（Ⅶ）。

Five anti-cancer compounds were isolated from the dried root of Momordica dioica Koxb. ex Willd. They were identified as bryonolic acid, 23, 24-dihydrocucurbitacin-F-25-acetate, a-spinasterol- 3-O-β-D-glucopyranoside; gypsogenin and hederagenin by spectroscopic (MS, IR, ^(1)HN MR, ^(13) CNMR and DEPT) data. All of them were found to possess anti-cancer activities against L_(1210), CCER--CEM, Ls174T cell lines by pharmacological screenings.