摘要
采用聚乙二醇４００制备了尼群地平软胶丸，其体外溶出度高于市售片剂。９名健康受试者交叉口服胶丸剂和片剂，胶丸剂的达峰时间（Ｔｍａｘ）明显提前，峰浓度（Ｃｍａｘ）增高，药时曲线下面积（ＡＵＣ）值增加，经统计学分析，两制剂的生物利用度有显著性差异。
Nitrendipine soft capsules were prepared using PEG400.The results of evaluation in vitro/in vivo showed that their dissolution rate and bioavailability in nine healthy volunteers were significantly higher than commercial tablets.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1999年第6期252-255,共4页
Chinese Journal of Pharmaceuticals
