血卟啉乙二醇醚类化合物的合成及其光动力抑瘤活性

HEMATOPORPHYRIN ETHYLENEGLYCOLYL ETHERS:SYNTHESIS AND PHOTODYNAMIC EFFECTS ON TUMOR

以氯化血红素为原料经加成、脱铁、醚化及水解合成了７个新的血卟啉乙二醇醚类化合物（１ａ～ｇ），１ａ～ｇ在Ｄ２Ｏ中对ＮＡＤＰＨ光氧化作用的敏化效应均高于ＨｐＤ，１ｂ对小鼠Ｓ１８０肉瘤的光动力损伤作用明显高于ＨｐＤ。

Seven new hematoporphyrin ethyleneglycolyl ethers were synthesized from hemin via addition,demetalation,eserification and hydrolysis.Their sensitizing effects on the photooxidation of NADPH and the photodynamic effects on the transplanted Sarcoma 180 were stronger than HpD.So these compounds might be developed as a kind of new photosensitizer in photodynamic therapy on tumor.