摘要
以氯化血红素为原料经加成、脱铁、醚化及水解合成了7个新的血卟啉乙二醇醚类化合物(1a~g),1a~g在D2O中对NADPH光氧化作用的敏化效应均高于HpD,1b对小鼠S180肉瘤的光动力损伤作用明显高于HpD。
Seven new hematoporphyrin ethyleneglycolyl ethers were synthesized from hemin via addition,demetalation,eserification and hydrolysis.Their sensitizing effects on the photooxidation of NADPH and the photodynamic effects on the transplanted Sarcoma 180 were stronger than HpD.So these compounds might be developed as a kind of new photosensitizer in photodynamic therapy on tumor.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1999年第6期258-260,共3页
Chinese Journal of Pharmaceuticals
关键词
血卟啉
乙二醇醚
合成
光动力疗法
肿瘤
抗癌药
hematoporphyrin ethyleneglycolyl ether,synthesis,photodynamic therapy,tumor