兰州市不同地区大气悬浮颗粒物的遗传毒性研究

Research on genotoxicity of TSP in various functional regions of Lanzhou city

目的为了研究兰州市不同功能区大气悬浮颗粒物的遗传毒性并对各区进行比较。方法用Ａｍｅｓ试验、人体外周血淋巴细胞微核试验和染色体畸变试验检测。结果对３种测试方法各试验条件下，不同功能区５个样品均具有不同程度的致突变作用。结论提示兰州市大气悬浮颗粒物具有潜在的致癌危险性。

Objective To study the genotoxicity and to compare the genotoxic intensities of organic extracts taken from total suspended particulates (TSP) in five various functional regions of Lanzhou city. Methods The mutagenic activity of organic extracts was assayed by Ames test,lymphocyte micronucleus test and chromosomal aberration test on human peripheral blood.ZResults The mutagenicity was present in the five extracts at various degrees and factors.The mutagenic intensity depended on the physical and chemical properties of TSP. Conclusions The results indicat that some potential carcinogenic risk might be present in TSP in Lanzhou city.