原发性高血压患者子女胰岛素抵抗的研究

The research on insulin resistance of the offspring of essential hypertension patients

目的观察原发性高血压（ＥＨ）患者的血压正常子女（ＮＴＯ）是否存在胰岛素抵抗，并分析与胰岛素受体（ＩｎＲ）的关系。方法检测３３例ＮＴＯ胰岛素抵抗状况，通过葡萄糖耐量试验、胰岛素释放试验计算胰岛素抵抗指数（ＩＲＩ），与无高血压病家族史的正常人及ＥＨ患者对比，同时测定红细胞ＩｎＲ，分析与ＩＲＩ的关系。结果ＩＲＩ强度依次为ＥＨ＞ＮＴＯ＞正常对照，ＩＲＩ与ＩｎＲ数目呈负相关。结论ＮＴＯ存在胰岛素抵抗，它的产生与ＩｎＲ缺陷有关，提示ＥＨ的胰岛素抵抗是原发性改变，并且与遗传有关。

bjective To observe if there exists insulin resistance on normal tension offspring(NTO) of essential hypertension (EH) patients,and analyse the relationship between insulin resistance and insulin receptor (InR). Methods Condition of insulin resistance was determined in 33 cases of NTO.Insulin resistance index(IRI) was calculated through glucose tolerance test and insulin release test,and then compared with EH patients and the normal people without EH family history while erythrocyte InR is tested and its relations with IRI were analysed.ZResults IRI was in turn EH>NTO>mormal controls,and IRI was negatively correlated with InR number. ConclusionsThere exists insulin resistance in NTO,and it has a relation to InR defect.It is suggested that EH insulin resistance is a primary variation and has a relation to heredity.