盐酸环丙沙星注射液治疗急性细菌性感染的临床评价

Clinical Evaluation of Ciprofloxacin Hydrochloride in Treatment of Acute Bacterial Infection

采用随机对照临床试验方法，用受试药盐酸环丙沙星注射液和对照药乳酸环丙沙星葡萄糖注射液治疗急性细菌性感染各６０例。结果两组有效率分别为８１．７％和８５．０％，不良反应发生率分别为１５．０％和１３．３％，其差异均无显著性意义（均为Ｐ＞０．０５）。盐酸环丙沙星体外抗菌活性与乳酸环丙沙星相似。结果表明，受试药与对照药用于治疗呼吸道和泌尿道等急性感染，疗效相似。

A randomized controlled clinical trial was conducted to evaluate the efficacy of ciprofloxacin hydrochloride injection in the treatment of bacterial infections Sixty patients with acute bacterial infection were treated with ciprofloxacin hydrochloride injection and another 60 patients with ciprofloxacin lactacid glucose injection as control The clinical efficacy rates of both drugs were 817% and 850%, respectively(P>005) and the bacteria clearance rate was 868% and 877%, respectively(P>005). Side effects were 150% and 133%, respectively(P>005) In vitro activity of ciprofloxacin hydrochloride against 102 clinical isolates manifested that this agent was highly active against Gramnegative baccilli and had fair activity against staphylococcus The results showed that ciprofloxacin hydrochloride injection had the same clinical efficacy as ciprofloxacin lactacid glucose injection and had high bacteria clearance rate The agent is suitable for treating the respiratory tract and urinary tract infection