论毒邪与骨髓增生异常综合征

Discussion on Pathogenic Toxin and Myelodysplastic Syndrome

通过回顾总结前人学说和相关文献中有关毒邪的涵义、分类、致病机理等理论,结合骨髓增生异常综合征(MDS)的病因病机及中医临床证治特点,阐述MDS的发生与"内毒"和"外毒"的关系,指出毒邪既是MDS的重要致病因素又是疾病过程中的病理产物,在MDS不同阶段必须权衡毒邪内停之轻重,适时、得当地采用清解邪毒法治疗,可以抑制骨髓异常增生,诱导造血干细胞的分化,促进MDS骨髓的正常造血。

We summarized the predecessors＇ academic views and reviewed the related literature of the theory of pathogenic toxin about its meaning, categories and pathogenesis, analyzed the etiopathogenesis and the traditional Chinese medical syndrome differentiation and treatment of myelodysplastic syndrome （MDS）, and then explored the relationship between the occurrence of MDS and external and internal toxin. It is pointed out that pathogenic toxin is not only one of the important pathogenic factors but also the pathological product in the progress of MDS. Judging the severity of pathogenic toxin in different stages of MDS, and then adopting the timely and proper treatment of removing and dispelling toxin can suppress the hyperplasia of bone marrow, induce the differentiation of hematopoietic stem cell, and promote normal hematopoiesis in bone marrow of MDS patients.