含矿物中成药及其胃肠消化液中五种重金属元素的测定研究

Determination of 5 Heavy Metals in Chinese Traditional Medicines and Extraction Liquid Containing Mineral Materials

传统含雄黄中成药中可能含有多种微量元素及高含量的砷等有毒元素。对含雄黄的三种中成药分别采用微波消解与电热板消解进行处理,用电感耦合等离子体质谱(ICP-MS)及电感耦合发射光谱(ICP-AES)法检测其中的As,Hg,Cu,Cd,Pb。此外,还研究了含雄黄中成药经模拟人工胃肠消化后消化液中有毒有害金属含量。结果显示,三种中成药中As,Hg,Cu,Cd,Pb总量变化范围分别为,As24350～68627mg·kg-1;Hg0.26～122313.6mg·kg-1;Cu2.04～6.95mg·kg-1;Cd0.02～1.46mg·kg-1;Pb0.42～40.60mg·kg-1;而人工胃肠消化液中含量分别为:As81～618mg·L-1;Hg0.34～216mg·L-1;Cu1.08～2.15mg·L-1;Cd和Pb未检出。上述结果为更加科学地评价中成药对人体健康的影响提供了数据基础。

Chinese traditional medicine （CTM） containing realgar may contain high levels of toxic metals, such as arsenic, etc. The monitoring of trace elements, especially the harmful elements, is closely related to the quality control of the CTM. Three kinds of CTM containing realgar were digested by microwave method and electric heating plate method, and As, Hg, Cu, Cd and Pb were determined using ICP-MS and ICP-AES. In addition, this research determined the content of soluble heavy metals in the human gastrointestinal solution. The results showed that three kinds of CTM contained As of 24 350~68 627 mg·kg-1; Hg of 0.26~122 313.6 mg·kg-1; Cu of 2.04~6.95 mg·kg-1; Cd of 0.02~1.46 mg·kg-1; Pb of 0.42~40.60 mg·kg-1. In comparison, the contents of soluble heavy metals in the human gastrointestinal solution are： As of 81~618 mg·L-1; Hg of 0.34~216 mg·L-1; Cu of 1.08~215 mg·L-1, and Pb, Cd were not detected.