精神刺激降低裸鼠表皮CD44水平

Psychological Stress Down-regulates Epidermal CD44 Level in Murine Model

目的确定精神刺激对表皮CD44的表达是否有影响。方法利用限制裸鼠自由活动的方法建立精神刺激模型,并于造模结束时用胶带破坏其躯干部表皮通透屏障功能。用免疫组化法观察CD44在完整的表皮及屏障功能破坏6h后表皮的表达。结果与对照组相比,在精神刺激后,无论是完整的,还是表皮通透屏障功能破坏的皮肤,其表皮CD44的表达都明显降低;两组之间,透明质酸的表达没有明显差别。结论精神刺激能降低表皮CD44的表达。

Objective To determine whether psychological stress regulates the epidermal CD44 level. Methods Psychological stress model was established by immobilization of hairless mice. Skin sample were taken from intact skin and 6hr after acute barrier abrogation by repeated tape stripping. Epidermal CD44 level in both intact skin and 6 hr after barrier disruption was assessed by irnmunohistochemistry methods. Results In comparison with control mice, psychological stress reduced epidermal CD44 level in both intact skin and 6 hr after barrier disruption. No significant difference in cutaneous hyaluronic acid level between control and stressed mice was observed. Conclusion Psychological stress down-regulates epidermal CD44 level.