神经酰胺与皮肤屏障

Ceramide and Skin Barrier Function

神经酰胺是人体角质层脂质的主要成分,在皮肤的合成和分布有一定的规律。其质和量的变化可以导致脂质结构的改变,从而影响皮肤屏障功能。不同亚型神经酰胺作用不同,在角质形成细胞增殖、分化及凋亡中起重要作用,是皮肤屏障损伤修复后期重要的效应物质。许多皮肤病可导致角质层屏障功能的破坏,而屏障功能的破坏又是一些皮肤病的病因或加重因素。故神经酰胺在皮肤中的作用越来越受重视。

Ceramide is one of the lipids in human stratum corneum. The alteration of the ceramide will lead to the change of the lipids, and then the destruction of skin barrier function happens. It plays an important role in the proliferation, differentiation and apoptosis of keratinocytes. Many dermatogic diseases can destroy skin barrier function, and the destruction of barrier function will also result in skin diseases or aggravate the dis- eases. In a word, increasing attentions are paid to the ceramide＇s function in the skin.