内皮素、前列环素与血栓素在妊娠高血压综合征发病中的作用

Roles of Endothelin,Prostacyclin and Thromboxane in the Pathogenesis ofPregnancy Induced Hypertension Syndrome

【目的】为探讨内皮素（ＥＴ－１）、前列环素（ＰＧＩ２）、血栓素（ＴＸＡ２）在妊娠高血压综合征（妊高征）发病中的作用。【方法】应用放射免疫法测定５５例妊高征患者，２３例正常妊娠妇女血浆ＥＴ－１，ＰＧＩ２，ＴＸＡ２浓度。【结果】①妊高征患者血浆ＥＴ－１浓度高于正常妊娠妇女，且随病情加重而上升。②中、重度妊高征患者血浆ＰＧＩ２较正常妊娠妇女低，中、重度妊高征患者血浆ＴＸＡ２较正常妊娠妇女高，两者随妊高征病情加重而下降或上升。③中、重度妊高征患者血浆ＥＴ－１与ＰＧＩ２呈负相关，与ＴＸＡ２呈正相关，ＰＧＩ２与ＴＸＡ２呈负相关。【结论】①ＥＴ－１，ＰＧＩ２，ＴＸＡ２可作为判断妊高征病情的指标。②ＥＴ－１可能是妊高征发病的主要原因。③ＰＧＩ２对ＥＴ－１具有拮抗作用，推测补充外源性ＰＧＩ２可能成为治疗妊高征的有效途径。

To study the roles of endothelin(ET-1),prostacyclin (PGI2) and thromboxane (TXA2) in the pathogenesis of pregnancy induced hypertension syndrome(PIHS). Plasma levels of ET-1,PGI2 and TXA2 were estimated by radioimmunoassay(RIA) mothod in 55 patients with PIHS and 23 healthy pregnant women. The plasma levels of ET-1 in patients with PIHS were significantly higher than those in healthy pregnant women,rising with the aggravation of disease.The plasma levels of PGI2 in patients with moderate and severe PIHS were significantly decreased as compared with those in healthy pregnant women;whereas the plasma levels of TXA2 in these patients were higher than those in healthy pregnant women.Both levels fluctuated to the decreasing or increasing side with the deterioration of the patients respectively.There were a negative correlation between plasma ET-1 and PGI2 and a positive correlation between plasma ET-1 and TXA2 in patients with moderate and severe PIHS.The plasma levels of PGI2 were negatively correlate .Plasma levels of ET-1,PGI2 and TXA2 could be used as reliable indicators for judging the severity of PIHS.ET-1 may be a main predisposing cause of PIHS;We infer that it is an effective way to supplement exogenous PGI2 in the treatment of PIHS according to the antagonistic action of PGI2 towards ET-1.