SAS患者血清中NO含量的临床意义

Role of nitric oxide in pathogensis of complicationsin obstructive sleep apnea

目的通过检测睡眠呼吸暂停综合征患者（ＳＡＳ）血清中一氧化氮（ＮＯ）的含量，预测其与ＳＡＳ患者多系统器官损害的关系。方法用ＮＯ３／ＮＯ２法测定ＳＡＳ有并发症组（Ⅰ组）、ＳＡＳ无并发症组（Ⅱ组）及对照组（Ⅲ组）睡前及醒后血清中的ＮＯ含量。结果Ⅰ组患者睡前血清中ＮＯ含量与其它两组相比无显著差异（Ｐ＞００５）；睡醒后Ⅰ组与Ⅱ、Ⅲ组相比ＮＯ含量明显增高（Ｐ＜００１及Ｐ＜００５）。结论ＮＯ是ＳＡＳ患者发生各系统严重并发症的重要信息物质之一，它的生成过量将导致ＳＡＳ患者明显的多系统器官损害。

Objective To investigate the role of nitric oxide(NO)in pathogenesis of complications in obstructive sleep apnea(OSA).Methods Sixty-six OSA patients divided into two groups:Thirty-two with the complications;Thirty-four without the compplications,The other 30 healthy subjects served as the control.Peripheral venous blood samples were obtained before and after sleep.The serum NO content and NO synthetase activity levels were analyzed with NO3/NO2 method. Results The serum NO content had no significant differences before sleep in all groups (P>005) and parently increased in the comparison of group with the other two groups (P<005,P<001) after sleep.Conclusion NO might contribute to the development of the pathogensis of complications in OSA.Excessive NO production may play an important role in the pathogensis of complications in OSA.