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成纤维细胞生长因子23与慢性肾病的研究 被引量：1

Research on Fibroblast Growth Factor-23 and Chronic Kidney Disease
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摘要 成纤维细胞生长因子23与人类许多疾病相关,它不仅可以直接调节钙、磷代谢,而且可以间接调节甲状旁腺激素、维生素D代谢。FGF23和klotho蛋白对维持磷酸盐的浓度、血管和骨骼都具有其独特的意义。主要通过与磷酸盐对比,提出了FGF23可以独立预测慢性肾病的不利结果,最后指出FGF23抗体和其C-末端在慢性肾脏疾病的治疗上具有潜力。 Many human diseases are associated with FGF23 ,it can directly regulate calcium and pbospborus metabolism and can indirectly regulate parathyroid hormone,vitamin D metabolism.FGF23 and klotho is related to the leve of phosphate,blood vessels and bone.Compare with phosphates ,it showed that FGF23 can predict the adverse outcomes of chronic kidney disease, finally it was pointed out that the antibody of FGF23 and C-terminal had potential in the treament of chronic kidney disease.
作者 孙常文 刘孝菊 陈玉斌 李校堃
机构地区 吉林农业大学生物反应器与药物开发教育部工程研究中心 吉林农业大学生命科学学院 吉林大学公共卫生学院 温州医学院药学院
出处 《现代农业科技》 2011年第1期11-12,14,共3页 Modern Agricultural Science and Technology
关键词 FGF23 慢性肾病 磷酸盐 研究 FGF23 chronic kidney disease phosphates research
分类号 R329.25 [医药卫生—人体解剖和组织胚胎学]
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参考文献8

  • 1HSUHJ, WUMS.Fibroblast growth factor 23 :a possible cause of left ventricular hypertrophy in hemodialysis patients[J].Am J Med Sci ,2009 (337) : 116-122.
  • 2KOMABA H, FUKAGAWA M.FGF23 -parathyroid interaction : implications in chronic kidney disease[J].Kidney Int ,2010(77) :292-298.
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同被引文献8

  • 1全国eGFR课题协作组.MDRD方程在我国慢性肾脏病患者中的改良和评估[J].中华肾脏病杂志,2006,22(10):589-595. 被引量：702
  • 2Shlipak MG, Massie BM.The clinical challenge of cardiorenal syndrome[J].Circulation, 2004, 110 ( 12 ) : 1514- 1517.
  • 3Ronco C, Haapio M, House AA, et al.Cardiorenal Syndrome[J].J Am Coil Carcliol, 2008, 52 ( 19 ) : 1527-1539.
  • 4Shimada T, Mizutani S, Muto T, et al.Cloning and characterization of FGF23 as a causative faclor of tumor- induced osteomalacia[J].Proc Natl Acad Sci USA, 2001, 98 ( 11 ) : 6500-6505.
  • 5Gruson D, Lepoutre T, Ketelslegers JM, et al. C-terminal FGF23 is a strong predictor of survival in systolic heart failure[J].Peptides, 2012, 37 (2) : 258-262.
  • 6Ronco C, McCullough P, Anker SD, et al.Cardio-renal syndromes:report from the consensus conference of the acute dialysis quality initiative[J]. Eur Heart J, 2010, 31 (6) : 703-711.
  • 7Faul C, Amaral AP, Oskouei B, et al. FGF23 induces left ventricular hypertrophy[J]. J Clin Invest, 2011, 121 ( 11 ) : 4393-4408.
  • 8杨峻,宦红娣,张军力,吴晓梅,张景红.血清成纤维细胞生长因子23在慢性肾功能衰竭中的相关性研究[J].检验医学,2009,24(10):711-714. 被引量：5

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现代农业科技
2011年 第1期

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