食管鳞癌nm23-H1表达及其临床意义

Expression of nm23H1 in Esophageal Carcinoma and its Significance

为了探讨肿瘤转移抑制基因蛋白（ｎｍ２３Ｈ１）的表达与食管鳞癌的临床病理特点及预后的关系，采用免疫组化ＳＰ法检测５５例食管鳞癌的ｎｍ２３Ｈ１的表达情况。结果显示５５例食管癌中，ｎｍ２３Ｈ１表达阳性率为５４．５％（３０／５５）。食管癌患者术后５ａ生存率与ｎｍ２３Ｈ１阳性表达率有明显正相关（Ｐ＜０．０５）。淋巴结转移者的ｎｍ２３Ｈ１阳性率（３８．９％）明显低于无淋巴结转移者（７５％，Ｐ＜０．０５）。患者性别、肿瘤大小、肿瘤分化程度及浸润深度与ｎｍ２３Ｈ１阳性表达率无关（Ｐ＜０．０５）。结果表明：ｎｍ２３Ｈ１可作为一种食管癌淋巴结转移及预后的重要生物学指标。

In order to study the significance of nm23H1 expression in esophageal carcinoma,55 cases were studied immunohistochemically.The results showed that the expression rate of nm23H1 was 54.5%(30/55).The nm23H1 expression was positively correlated to postoperation survival(5 year,P<0.05) and negatively to lymph node metastasis.There was no significant correlation between the expression of nm23H1 and clinicopathologic findings,such as sex,depth of invasion,tumor size,histopathologic classification.These results suggest that nm23 gene may play an important role in inhabition from metastasis of esophageal carcinoma,and may serve as an indicator to predict the prognosis of patients with esophogeal carcinoma.