肝动脉化疗灌注结合外放射治疗大肝癌30例分析

Effects of Hepatic Arterial Infusion Chemotherapy(HAI) Combined withExternal Irradiation in Treating 30 Cases of Large Primary Liver Cancer

为了评价肝动脉化疗灌注（ＨＡＩ）结合外放射对不适宜做动脉栓塞（ＴＡＥ）治疗的肝癌患者的疗效。采用ＨＡＩ结合外放射的方法治疗不适宜做ＴＡＥ治疗的原发性大肝癌３０例。总有效率（ＣＲ＋ＰＲ）４０．０％，１，３，５ａ生存率分别为５８．４％，２０．２％，７．８％，平均生存期１３．６个月。多数病例能耐受治疗，但３例ＣｈｉｌｄＣ级病例中，有２例死于因治疗所致的肝功能衰竭。结果提示ＨＡＩ结合外放射是治疗不适宜行ＴＡＥ的大肝癌的有效方法，但不适于ＣｈｉｌｄＣ级患者。

To evaluate the therapeutic efficacy of HAI combined with external radiotherapy for primary liver cancer which transcatheter arterial embolization(TAE) is not suitable for,thirty patients underwent the combined therapy.The response rate(CR+PR) was 40.0%.The survival rates at 1,3,and 5year were 58.4%,20.2%,and 7.8%,respectively.The mean survival time was 13.6 months.Most of patients tolerated the combination therapy,but two of 3 patients with Child C grade died of liver failure associated with the therapy.The results suggest that HAI combined with radiotherapy is effective for liver cancer which TAE is not suitable for.But the patients with Child C grade are not indication of the combined therapy.