黄芩甙对异丙肾上腺素诱导大鼠心肌损伤的保护作用

Protecting Effects of Baicalin on Isoprenalineinduced Myocardial Injury in Rats

利用异丙肾上腺素造成大鼠急性心肌缺血模型，观察黄芩甙对大鼠缺血心肌的保护作用。２８只Ｗｉｓｔａｒ大鼠分为正常对照组、缺血模型组、黄芩甙Ⅰ组、黄芩甙Ⅱ组。观察黄芩甙对各组大鼠心电图、血清磷酸肌酸激酶及心肌组织超氧化物歧化酶（ＳＯＤ）和脂质过氧化物丙二醛（ＭＤＡ）的影响。结果表明，黄芩甙可对抗异丙肾上腺素所致大鼠急性心肌损伤，使心肌缺血大鼠的心电图ＳＴ段异常抬高数减少，血清磷酸肌酸激酶（ＣＰＫ）降低，并可增加心肌组织ＳＯＤ的活力，减少ＭＤＡ生成。提示黄芩甙对大鼠心肌缺血有保护作用，其机制可能与抗脂质过氧化反应有关。

Protective effects of baicalin on acute myocardial injury induced by isoprenaline were studied in rat. Animals were seperated into four groups of control myocardial ischemia model baicalin and baicalin . The effects of baicalin on electro cardiogram, serum CPK and myocardial malonialdehyde (MDA) and superoxide dismutase (SOD) were observed in rats. The results showed that baicalin inhibited the raising of ST period, depressed the release of CPK, reduced myocardial MDA production, protected myocardial SOD activity in the isoprenalineinduced damege of rat heart. The results suggested that baicalin possessed protective effects on ischemic myocardium and the action was considered to be related to the inhibition of lipid peroxidation.