P53、nm23、CD44及FN表达与大肠癌淋巴结转移的关系

The Relation between the Expression of P53, nm23, CD44, FN and Lymph Node Metastasis of Colorectal Carcinoma

对７３例原发性大肠癌（淋巴结转移３７例，非转移３６例）进行Ｐ５３、ｎｍ２３、ＣＤ４４及纤维粘连蛋白（ＦＮ）免疫组化检测，研究其表达与淋巴结转移的关系。结果显示，ｎｍ２３阴性表达与ＣＤ４４阳性表达在淋巴结转移组与非转移组之间有显著性差异（Ｐ＜０．０１）。２项指标串联筛检，预测淋巴结转移的特异性为９７．２２％，敏感性为５６．７６％。ｎｍ２３表达水平与大肠癌淋巴结转移呈负相关，ＣＤ４４则呈正相关，２项指标联合应用可作为预测淋巴结转移的１项比较客观的指标。

To assess the relationship of P53, nm23, CD44 and FN with lymph node metastasis of colorectal carcinoma, the expression of the four proteins was examined from 73 cases of colorectal carcinomas(37 cases with lymph node metastasis and 36 cases without metastasis) using immunohistochemical method. The low expression of nm23 and the positive expression of CD44 were significant difference between metastasis group and nonmetastasis(P<0.01). When using the combination of nm23 and CD44 to predict the lymph node metastasis, the specificity was 97.22%, and the sensitivity was 56.76%. An inverse correlation was observed between nm23 expression and lymph node metastasis. While CD44 expression showed a positive correlation. The combination of the two tests may be used as Author a objective parameter in predicting the lymph node metastasis of colorectal carcinoma.