摘要
目的:考察卡络磺钠注射液与注射用加替沙星在0.9%氯化钠注射液中的配伍稳定性。方法:采用反相高效液相色谱法-二极管阵列检测器同时测定卡络磺钠注射液与注射用加替沙星在0.9%氯化钠注射液中配伍后,分别在25、37℃放置12h内各时间段的含量,并测定pH值,观察配伍液的外观变化。结果:在25、37℃下、12h内,配伍液外观、pH值及含量均无明显变化。结论:在25、37℃下,卡络磺钠注射液与注射用加替沙星在0.9%氯化钠注射液中在12h内可配伍使用。
OBJECTIVE: To study the compatibility of Carbazochrome sodium sulfonate injection and Gatifloxacin for injection in 0.9% sodium chloride injection. METHODS: Carbazochrome sodium sulfonate injection was combined with gatifloxacin for injection in 0.9% sodium chloride injection. The contents of carbazochrome sodium sulfonate and gatifloxacin in mixture were determined by RP-HPLC-DAD at 25 ℃ or 37 ℃ within 12 h and external appearance and pH were observed. RESULTS: There was no significant change in appearance, pH and the content of carbazochrome sodium sulfonate and gatifloxacin under two temperature conditions within 12 h. CONCLUSION: Carbazochrome sodium sulfonate injection combined with gatifloxacin for injection in 0.9% sodium chloride injection can be used within 12 h at 25 ℃ and 37 ℃.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第2期149-151,共3页
China Pharmacy