黄芩的化学成分研究

Study on Chemical Constituents of Scutellaria baicalensis

目的:研究中药材黄芩根茎氯仿部位的化学成分。方法:利用硅胶柱色谱色谱、制备薄层色谱技术对黄芩氯仿部位进行分离,纯化。通过波谱数据对化合物进行结构解析。结果:从黄芩根茎的氯仿部位分离、纯化得到10个化合物,分别鉴定为:β-谷甾醇(1),苯甲酸(2),千层纸素-A(3),汉黄芩素(4),黄芩素(5),5,7-二羟基-6-甲氧基二氢黄酮(6),黄芩黄酮-Ⅱ(7),6,7,8-三甲氧基-5,2′-二羟基黄酮(8),5-甲氧基-7-羟基二氢黄酮(9),5,7,2′,5′-四羟基-8,6′-二甲氧基黄酮(10)。结论:化合物(9)为在该植物中首次发现。

Objective： Study the chemical constituents of the radixs of Scutellaria baicalensis. Method： Use column chromatography and preparation thin layer chromatography to separateand purify the compounds. Structure analysis were carried out by buclear magnetic resonance （NMR） technology. Result： Ten compounds were separated and purified from chloroform parts of S. baicalensis, and identified as β-sitosterol （ 1 ）, benzoic acid （2）, oroxylin-A （ 3 ）, wogonin （ 4 ）, baicalein （ 5 ）, dihydroroxylinA （ 6 ）, skullcapflavone- Ⅱ （ 7 ）, tenaxin- Ⅰ （ 8 ）, 5-methoxy- 7-hydroxyflavonone （ 9 ）, 5,7,2＇, 5 ＇-tetrahydroxy-8,6＇-dimethoxyflavone （ 10 ）. Conclusion ： Compound （ 9 ） were discovered from S. baicalensis for the first time.