二次打击与恶性淋巴瘤发生的研究进展

Research Progress on Second-Hit in Malignant Lymphomagenesis——Review

干/祖细胞对于组织器官正常发育有积极作用,但它们的基因突变可能导致许多人类疾病,包括癌症。经二次打击后基因突变的干/祖细胞是肿瘤的起源,并称为肿瘤干/祖细胞。目前对于非霍奇金淋巴瘤的干/祖细胞研究也证实,存在一群有干/祖细胞特性的细胞,它们的突变可能导致B细胞性淋巴瘤的发生。本文就近年有关二次打击与非霍奇金淋巴瘤发生的研究进展进行综述。

Stem/progenitor cells contribute to normal development of organs, but their mutation may lead to many human diseases including cancer. Stem/progenitor cells and some of the cancer cells have the same abilities of self-renewal and differentiation, suggesting that tumors were initiated from mutated stem/progenitor cells, the cancer stem/progenitor cells. The recent studies on the origin of the non-Hodgkin′s lymphomas has proved that the second-hit aggravates gene mutation in lymphocytic progenitor cells, leading to the generation of lymphoma. This review summarizes the current advances in the studies of the second-hit at stem/progenitor cells in oncogenesis of B-cell non-Hodgkin′s lymphoma.