脉搏波速度与冠状动脉病变严重程度的相关性研究

Relationship between Pulse Wave Velocity and Severity of Coronary Artery Disease

目的研究颈-股脉搏波速度(carotid-femoral pulse wave velocity,C-FPWV)与冠状动脉病变严重程度的相关性,评价C-FPWV对冠状动脉狭窄程度的预测价值。方法连续入选因疑诊冠心病行冠状动脉造影的患者126例,其中男性61例,女性65例,年龄30～80(62.83±9.38)岁。冠状动脉造影前采用Artech-Medical公司的康普乐(CompliorSP)检测C-FPWV,冠状动脉病变严重程度用冠状动脉病变支数及冠状动脉病变Gensini积分来表示。结果冠状动脉三支病变组C-FPWV明显高于无病变组(P=0.001)。一元线形相关分析显示C-FPWV与冠状动脉Gensini积分明显相关;logistic回归分析显示:性别、C-FPWV是有无冠状动脉三支病变的独立预测因子。结论 C-FPWV与冠状动脉病变严重程度密切相关,是冠状动脉三支病变的独立预测因子,增高的C-FPWV有可能作为心血管病的一个危险信号,指导早期干预治疗。

Objective To study the relationship between carotid-femoral pulse wave velocity（C-F PWV） and severity of coronary artery disease（CAD）,evaluate the usefulness of C-F PWV to predict the extent of coronary atherosclerosis lesions.Methods A total of 126 patients with suspected CAD were selected.C-F PWV was measured using an automatic device（Complior SP,France）.The severity of coronary artery disease was evaluated by the number of diseased arteries and Gensini score.Results The value of C-F PWV in the group with 3-vessel disease was significantly higher than that in the group without CAD（P=0.001）.Univariate linear regression analysis showed that C-F PWV was related to Gensini score,with correlation coefficient R=0.701.Logistic regression analysis showed that gender and C-F PWV are the independent predictor of 3-vessel coronary artery disease.Conclusion C-F PWV was significantly correlated with the extent of coronary artery stenosis,and high C-F PWV can be regarded as an independent predictor of 3-vessel coronary artery disease.So high C-F PWV may be regarded as a marker of CAD,which is helpful to evaluate the severity of coronary atherosclerotic heart disease.