三种不同炎性因子联合多层螺旋CT对结肠癌术前分期与术式预测的比较研究

Use of inflammatory factors combined with multi-slice spiral computer tomography for preoperative staging and operative strategy in colon cancer

目的 探讨纤维蛋白原（FIB）、血清淀粉样蛋白（SAA）和C反应蛋白（CRP）联合64排多层螺旋CT（MSCT）在结肠癌术前评估与术式预测中的临床价值.方法 前瞻性纳入2007年11月至2009年7月期间四川大学华西医院结直肠外科专业组收治住院的结肠癌患者315例,按电脑生成的随机数字表随机分配至MSCT联合CRP组（术前行MSCT联合CRP评估）、MSCT联合FIB组（术前行MSCT联合FIB评估）以及MSCT联合SAA组（术前行MSCT联合SAA评估）,每组105例,将患者的术前分期和术式预测与术后病理分期及实际术式进行比较.结果 3组患者基线情况一致（P＞0.05）.MSCT联合CRP组术前T、N、M分期和TNM分期准确度分别为65.7%、72.4%、100%和66.7% MSCT联合FIB组术前T、N、M分期和TNM分期准确度分别为71.4%、74.3%、99.0%和65.7% MSCT联合SAA组术前T、N、M分期和TNM分期准确度分别为60.0%、55.2%、96.2%和51.4%.MSCT联合CRP组与MSCT联合FIB组在术前N分期与TNM分期的准确度均优于MSCT联合SAA组（P＜0.05）,而MSCT联合CRP组与MSCT联合FIB组之间差异无统计学意义（P＞0.05）.3组手术方案预测的符合率分别为93.3%、92.3%和87.6%,差异无统计学意义（P＞0.05）.结论 MSCT联合CRP或FIB在结肠癌术前分期中拥有更高的准确度,其临床价值可能优于MSCT联合SAA.

Objective To determine the clinical value of C-reactive protein（CRP）, fibrinogen （FIB）, or serum amyloid A protein （SAA） combined with 64 multi-slice computed tomography （MSCT） for preoperative staging and operative strategy in colon cancer. Methods Patients with colon cancer were prospectively enrolled at the West China Hospital of Sichuan University from November 2007 to July 2009,and were equally randomized into 3 groups undergoing different preoperative evaluation： MSCT combined with CRP（CRP group）, MSCT combined with FIB （FIB group）, and MSCT combined with SAA （SAA group）. The agreement between preoperative staging and postoperative pathologic staging and that between expected surgical procedure and procedure adopted were compared. Results Baseline characteristics among three groups were similar（P〉0.05）. In CRP group, the accuracies of preoperative staging T, N, M and TNM were 65.7%, 72.4%, 100% and 66.7%, respectively. In FIB group, the accuracies of preoperative staging T, N, M and TNM were 71.4%, 74.3%, 99.0% and 65.7%, respectively. In SAA group, the accuracies of preoperative staging T, N, M and TNM were 60.0%, 55.2%, 96.2%and 51.4%, respectively. The accuracies of N and TNM staging in CRP group and FIB group were significantly higher than those in SAA group（P〈0.05）. However, there were no significant differences between FIB and CRP group（P〉0.05）. There were no significant differences in accuracy of predicting surgical procedures among three groups（93.3%, 92.3% and 87.6%, P〉0.05）. Conclusion Combined assessment of MSCT and CRP or FIB may improve the accuracy of preoperative staging and procedure prediction, and is superior to MSCT combined with SAA.