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原发性胃癌中细胞凋亡易感基因扩增的研究

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摘要 目的 探讨原发性胃癌中CAS基因扩增情况及其与胃癌临床病理学特征之间的关系.方法 用实时荧光定量PCR方法检测37例胃癌中CAS基因DNA拷贝数.结果 原发性胃癌中CAS基因平均拷贝数显著高于癌旁组织（0.771比0.437,P＜0.05） CAS扩增率为29.7%（11/37）.淋巴结转移者CAS基因扩增率高于无淋巴结转移者（45.0%比11.8%,P＜0.05）.结论 CAS基因可促进胃癌的形成,并与胃癌的淋巴结转移关系密切.
作者 朱亚青 朱正纲 刘炳亚 陈雪华 尹浩然
机构地区 上海交通大学附属瑞金医院外科上海消化外科研究所 江苏省常州市第三人民医院普通外科
出处 《中华胃肠外科杂志》 CAS 北大核心 2010年第11期856-858,共3页 Chinese Journal of Gastrointestinal Surgery
关键词 胃肿瘤 细胞凋亡易感基因 基因扩增
分类号 R735 [医药卫生—肿瘤]
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参考文献9

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中华胃肠外科杂志
2010年 第11期

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