含L-脯氨酸的手性树枝形化合物的合成和表征

SYNTHESIS AND CHARACTERIZATION OF CHIRAL DENTRIMER WITH L-PROLINAMIDE ARCHITECTURE

从2,4,6-三氯-1,3,5-三嗪出发,通过引入3个L-脯氨酸单元制备了一种新型的C3-对称的手性中心核,并以此手性中心核为基础,经过乙二胺胺解、丙烯酸甲酯迈克尔加成反应,合成了一种含L-脯氨酸单元的手性树枝形化合物。产物通过FT-IR、~1H NMR、^(13)C NMR和MS进行了表征。

A novel of class of low generation C3-symmetric core chiral dendrimers was designed. The low generation chiral dentrimer with L-prolinamide architecture has been synthesized by using 2,4,6-trichloro-l,3,5-triazine as dentric core by means of substitution reaction with L-proline to form the chiral core, and then amindation reaction and Michael addition reaction with ethylenediamine and methyl acrylate to form dentrimer containing chiral core. The structures of the compounds were char-acterized by FT-IR, 1H NMR, 13C NMR and MS.