4Frenkel D,Puckett L,Petrovic S,et al.A nasal proteosome adjuvant activates microglia and prevents amyloid deposition[J].Animal of Neurology,2008,63(5):591-601.
5Chabot S,Brewer A,Lowell G,et al.A novel intranasal ProtollinTM-based measles vaccineinduces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice[J].Vaccine,2005,23 (11):1374-1383.
6Orr N,Robin G,Cohen D,et al.Immunogenicity and efficacy of oral or intranasal Shigella flexneri 2a and shigella sonnei proteosome-lipopolysaccharide vaccines in animal models[J].Infect Immun,1993,61 (6):2390-2395.
8Jones T,Cyr S,Allard F,et al.ProtollinTM:a novel adjuvant for intranasal vaccines[J].Vaccine,2004,22(27):3691-3697.
9Hu M C,Jones T,Kenney R T,et al.Intranasal Protollin-formulated recombinant SARS S-protein elicits respiratory and serum neutralizing antibodies and protection in mice[J].Vaccine,2007,25(34):6334-6340.
10Tsai C M.The analysis of lipopolysaccharide (endotxin) in Meningococcal polysaccharide vaccines by silver staining following SDS-polyacrylaminde gel electrophoresis[J].J Biol,1986,14 (1):25-33.
5Plante M,Jones T,Allard F,et al.Nasal immunization with subunit proteosome influenza vaccines induces serum HAI,mucosal IgA and protection against influenza challenge.Vaccine,2002,20(1-2):218-225.
6Mallett CP,Hale TL,Kaminski RW,et al.Intranasal or intragastric immunization with proteosome-Shigella lipopolysaccharide vaccine protects against lethal pneumonia in a murine model of Shigella infection.Infect Immun,1995,63(6):2382-2386.
7Zollinger WD,Mandrell RE,Griffiss JM,et al.Complex of meningococcal group B polysaccharide and type 2 outer membrane protein immunogenic in man.J Clin Invest,1979,63(5):836-848.
9FRASER S A,De HAAN L,HEARN A R,et a1.Mutant Escherichiacoli heat-labile toxin B subunit that separate toxoid-mediated signalingand immunomodulatory action from trafficking and delivery functions[].Infection and Immunity.2003
10ANGSTROM J,BACKSTROM M,BEMTSSON A,et a1.Delineationand comparisonof canglioside-binding epitopes for the toxins of Vibriocholerae,Escherichia coli,and Clostridium tetani:evidence for overlap-ping epitopes[].Journal of Biological Chemistry.2000