细菌多糖的生物合成机制

Biosynthesis mechanisms of bacterial polysaccharide—A review

近些年来,细菌多糖因其重要的医学价值和工业用途引起了人们的广泛关注。随着细菌基因组的不断测序,众多与细菌多糖合成相关的基因簇被发现。不同多糖合成基因簇的比对分析结果表明,尽管自然界中多糖的结构复杂多变,但是它们的合成机制却是相对单一的。本文就当前国际国内不同细菌多糖的合成机制,以及多糖合成途径中相关糖基转移酶和聚合酶的研究进展进行了论述。

Bacterial polysaccharides play important roles both in medicine and industry.Due to the development of bacterial genome sequencing,many gene clusters related to the biosynthesis of bacterial polysaccharide have been found,aligned and analyzed.Despite of their complex composition and structures,different bacterial polysaccharides are biosynthesized via similar pathways.This review discussed the research development of the biosynthetic mechanism of different bacterial polysaccharides,with emphasis on the glycosyltransferases and polymerases involved in the biosynthetic pathway.