3,5-二碘-L-酪氨酸的合成新工艺

New process for synthesis of 3,5-diiodo-L-tyrosine

一氯化碘碘代合成标题化合物。结果表明,一氯化碘碘代的最佳反应条件:V(醋酸溶剂)∶V(一氯化碘)=8∶1,n(一氯化碘)∶n(L-酪氨酸)=3.6∶1,反应温度60℃。在此反应条件下标题化合物合成收率达90%以上,其结构经1HNMR表征确认。

3,5-Diiodo-L-tyrosine was prepared via iodization of iodine monochloride.Experimental results showed that the optimal conditions for iodization of iodine monochloride were as follows：the volume ratio of acetic acid solvent to iodine monochloride was 8∶1,the mole ratio of iodine monochloride to L-tyrosine was 3.6∶1,and the reaction temperature was 60 ℃.Under the optimal reaction conditions,the yield of 3,5-diiodo-L-tyrosine could reach up to 90%.The product structure was confirmed by 1HNMR spectroscopy.