山茱萸不同提取物降血糖作用研究

Effect of different extracts from Fructus Corni on decreasing blood glucose in mice

以正常小鼠和四氧嘧啶糖尿病小鼠为动物模型,分别对山茱萸乙醚提取物、乙酸乙酯提取物和乙醇提取物的降血糖作用进行研究。结果表明,山茱萸3种提取物组与模型组比较,均可显著降低四氧嘧啶糖尿病小鼠血糖水平(P<0.01)。山茱萸3种提取物组间比较,乙酸乙酯提取物组的降血糖作用最明显(P<0.05)。正常小鼠对照实验表明,山茱萸3种提取物对正常小鼠的血糖无明显影响(P>0.05)。本试验筛选出山茱萸乙酸乙酯提取物为山茱萸的降血糖活性成分。

Using nomal mice and alloxan diabetes mice as animal models, the effect of ether extracts, acetic ether extracts and alcohol extracts from Fructus Corni on decreasing blood glucose were studied. The results showed that compared with that of the diabetic model group, three extracts groups could obvious decrease the blood glucose of alloxan diabetes mice （P〈0.01）, among which the acetic ether extract group was the best one （P〈0.05）. Three extracts had no effect on the blood glucose of normal mice in comparison with normal control group （P〉0.05）. In this test, the acetic ether extracts from Fructus Corni was determined as the hypoglycemic active site.