摘要
目的观察中药扶正固本Ⅰ号方对晚期非小细胞肺癌(NSCLC)患者免疫功能及生活质量(QOL)的影响。方法将107例Ⅲ、Ⅳ期NSCLC患者随机分为化疗组(对照组)53例、化疗+中药组(治疗组)54例,分别给予单纯化疗和化疗结合扶正固本Ⅰ号方治疗。4个周期后,观察患者T细胞亚群、KPS评分、化疗毒副反应情况;SF-36调查表评估患者生活质量。结果治疗组治疗后CD3较治疗前明显提高(P<0.05),而对照组CD3、CD4化疗后较化疗前明显降低(P<0.05),治疗后治疗组CD4/CD8较对照组有明显提高(P<0.05);治疗组生活质量改善优于对照组(P<0.05);治疗组KPS评分稳定率高于对照组(P<0.05);对照组骨髓抑制较治疗组严重(P<0.05)。结论扶正固本Ⅰ号方能提高晚期NSCLC患者的免疫功能,改善生活质量,减轻化疗的毒副反应。
Objective To observe the effects of "Fuzheng Guben Decoction" on immune function and quality of life(QOL) in phase-Ⅲ and Ⅳ non-small cell lung cancer(NSCLC).Methods One hundred and seven patients with phase-Ⅲ and Ⅳ NSCLC were randomized into two groups:control group in which 53 cases were treated by chemotherapy only and treatment group in which 54 cases were treated by combined chemotherapy and "Fuzheng Guben Decoction".After 4 cycles,the T cell subsets,KPS score and chemotherapeutic side effects were observed;SF-36 questionnaire was used to assess the quality of life.Results After treatment,the content of CD3 was increased in the treatment group(P0.05),the contents of CD3 and CD4 were lowered in the control group(P0.05),the CD4/CD8 was higher in the treatment group than in the control group(P0.05);the quality of life was higher in the treatment group than in the control group(P 0.05);the KPS score was higher in the treatment group than in the control group(P0.05);the bone marrow suppression was more severe in the control group than in the treatment group(P0.05).Conclusion "Fuzheng Guben Decoction" can enhance advanced NSCLC patients’ immune function,improve quality of life and relieve chemotherapeutic side effects.
出处
《上海中医药杂志》
2010年第12期37-39,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市青浦区自然基金资助项目(2004-44)
关键词
非小细胞肺癌
扶正固本Ⅰ号方
免疫功能
生活质量
Non-small cell lung cancer
"Fuzheng Guben Decoction"
immune function
quality of life