合体滋养层细胞微粒对子痫前期重度病情进展的影响

Effects of syncytiotrophoblast microparticles on progressive severe preeclampsia

目的探讨合体滋养层细胞微粒(syncytiotrophoblast microparticles,STBM)在子痫前期重度病情进展中的作用。方法收集子痫前期重度33例,按照子痫前期重度临床发病特点和病情进展时间(从发病至发展为子痫前期重度是否大于48h)分为突发型(11例)和渐进型(22例),并随机选取同期正常健康剖宫产孕妇20例作为正常对照组,采用酶联免疫分析法(ELISA)测定母体外周血血浆中STBM浓度。结果突发型及渐进型子痫前期重度外周血血浆STBM浓度均明显高于对照组,差异有统计学意义(P<0.05)。突发型STBM浓度高于渐进型,差异有统计学意义(P<0.05)。结论 STBM脱落进入血液循环增多可能与子痫前期重度病情进展有关。

Objective：To explore the role of syncytiotrophoblast microparticles（STBM） in the disease development of severe preeclampsia.Methods：According to the onset pattern,33 cases of severe preeclampsia were divided into two groups： abrupt onset preeclampsia（11）,onset with gradual progress of severe preeclampsia（22）.20 cases of normal pregnancies as control were recruited.An ELISA was used to measure STBM levels in peripheral venous plasma.Results：STBM level in abrupt onset groups and gradual progress groups were significantly higher than those in control groups（P 0.05）.The level of STBM were increased in abrupt onset groups compared with gradual progress groups（P 0.05）.Conclusions： Shedding of STBM into the maternal circulation in higher amounts may correlate with the disease development of severe preeclampsia.