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同步放化疗后巩固化疗治疗局部晚期非小细胞肺癌22例 被引量：3

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摘要 目的:评价ⅢA、ⅢB期非小细胞肺癌(NSCLC)在同步放化疗后再给予巩固化疗的意义。方法:选取局部晚期NSCLC患者(ⅢA期和ⅢB期)采用同步放化疗后疗效达到CR、PR的患者进行随机两组:巩固化疗组:给予TC方案化疗4周期;对照组:给营养支持治疗。按WHO近期疗效及毒副标准评价治疗结果,用Ka-plan-Meier法计算生存率。结果:40例患者,巩固化疗组22例,对照组18例,巩固化疗组与对照组中位疾病无进展时间(TTP)分别为16.4个月比11.2个月(P=0.031),总体中位生存时间(OS)为21.8月比15.9月(P=0.044)。巩固化疗组毒副反应主要是骨髓抑制,能够耐受。患者1年KPS评分>60分者分别为77.2%(17/22)比83.3%(15/18)(P>0.05)。结论:巩固化疗对NSCLC同步放化疗后达到CR或PR的患者是有效且安全的治疗方案,能够改善无病生存时间。
作者 朱光军
机构地区 江苏省淮安市楚州人民医院放疗科
出处 《陕西医学杂志》 CAS 2010年第12期1604-1605,1610,共3页 Shaanxi Medical Journal
关键词 癌 非小细胞肺/放射疗法 癌 非小细胞肺/药物疗法 @巩固化疗
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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共引文献35

同被引文献24

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  • 2林贵山,程惠华,傅志超,李东石.晚期非小细胞肺癌同步放化疗的疗效分析[J].中华放射肿瘤学杂志,2006,15(6):462-466. 被引量：21
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引证文献3

二级引证文献6

陕西医学杂志
2010年 第12期

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