犬瘟热病毒引起啮齿类动物肥胖症的机制研究进展

Progress on the Mechanism of Rodent Obesity Caused by Canine Distemper Virus

在过去的30年中,已报道8种病原体可引起人和动物的肥胖,其中犬瘟热病毒是首个报道的可引起动物肥胖症的病毒。研究发现感染犬瘟热病毒的啮齿动物后期表现为病态肥胖。早期犬瘟热病毒的复制对感染鼠下丘脑造成不可逆的损伤,感染鼠表现为体重增加、脂肪细胞增大、体内瘦素受体表达水平下降、黑色素浓集激素前体(ppMCH)mRNA水平下降,高胰岛素血症,儿茶酚胺水平降低,这些因子与机体的食欲增强和(或)能量消耗减少有密切关系,与肥胖症的特征相一致。论文综述了有关犬瘟热病毒引起啮齿类动物肥胖症机制的研究进展。

Over the past thirty years,eight pathogens causing obesity in animals and human were reported.Canine distemper virus（CDV） is the first reported virus that causes obesity in animal.Most of rodents survivived from the infection with CDV slowly developed a morbid obesity syndrome.CDV induces hypothalamic lesion that are associated with active viral replication in infected rodents.Infected models have documented an increased body weight,produced enlarged fat cells and a number of physiologic changes,including decreased leptin receptor expression levels,decreased levels of prepromelanin concentrating hormone precursor（ppMCH） mRNA,hyperinsulinemia and decreased levels of catecholamine,which were found to be involved result in an increased food intake and/or a decreased energy expenditure that contribute to an increase in body fat in CDV infection.This review discussed the progress on the mechanism of rodent obesity caused by canine distemper virus.