健康成年人与血管性痴呆患者胼胝体及侧脑室体积的比较

Measurement of the volume of corpus callosum and lateral ventricle in normal adults and in patients with vascular dementia

目的：采用3.0T MRI对健康成年人及血管性痴呆患者胼胝体体积及侧脑室体积进行定量测量,探讨健康成年人不同年龄组、性别间胼胝体体积、侧脑室体积有无差别,并与血管性痴呆患者行对照研究。方法：选取健康成年人200例,男112例,女88例,年龄20-69岁,平均（42.81±13.43）岁;血管性痴呆患者31例,男15例,女16例,年龄45-86岁,平均（68.52±9.85）岁,采用3.0T MRI体积软件行侧脑室及胼胝体体积定量测量。结果：①健康成年人不同年龄组间侧脑室体积及胼胝体体积间均存在差别（P〈0.05）;②健康成年人男女不同性别间侧脑室体积及胼胝体体积之间比较差异亦具有统计学意义（P〈0.05）;③血管性痴呆患者组与老年健康对照组比较,侧脑室体积及胼胝体体积均有明显差别（P〈0.05）。结论：健康成年人60岁之前各年龄组间侧脑室体积无明显差别,60岁以后侧脑室体积扩大;健康成年人胼胝体体积在39岁之前随年龄增长有逐渐增大趋势,50岁以后体积逐渐萎缩,60岁后明显萎缩;男性侧脑室体积及胼胝体体积均较女性大;血管性痴呆组与老年健康对照组比较侧脑室明显扩大,胼胝体萎缩。

Objective：Using 3.0T MRI to measure the corpus callosum volume and lateral ventricle volume in normal adults and patients with vascular dementia and then to find its clinical significance in the diagnosis of vascular dementia.Methods：200 normal adults,112 males and 88 females,from 20 to 69 years old,with an average age of 42.81±13.43 years and 31 patients with vascular dementia,15 males and 16 females,from 45 to 86 years old,with an average age of 68.52±9.85 years,were selected in this study.The volumes of lateral ventricle and corpus callosum were measured by using 3.0T MRI volume software.Results：①There were differences among different age groups in both lateral ventricle volume and corpus callosum volume（P〈0.05）;②There were differences between men and women in both lateral ventricle volume and corpus callosum volume（P〈0.05）;③Compared with the healthy elderly group,the lateral ventricle volume and corpus callosum volume of vascular dementia patients were significantly different.Conclusions：There is no difference of the lateral ventricle volume in adults before 59 years old,the lateral ventricle volume is getting larger after 60 years old;the males＇ lateral ventricle volume and corpus callosum volume are larger than those of the females＇;The corpus callosum volume in normal adults before the age of 39 has a gradual increasing trend with age,before the age of 49 it does not change significantly,but gradually declines after the age of 50.In the vascular dementia group,the lateral ventricle becomes more dilated and the corpus callosum more atrophied than those of the healthy elderly control group.