摘要
综述了唑来膦酸(1)合成方法的研究进展。重点介绍了以咪唑为原料合成1的工艺条件,讨论了不同工艺条件的优缺点。结果显示,通过优选相转移催化剂和溶剂能高收率地合成1。参考文献30篇。
Research progress on the synthetic methods of zoledronic acid（1） was reviewed with 30 references.The technology conditions of synthesis of 1 from imidazole were mainly introduced.Advantages and disadvantages of different technological conditions were discussed.The results showed that 1 in high yield was synthesized by selective preference of the phase transfer catalyst and solvent.
出处
《合成化学》
CAS
CSCD
北大核心
2010年第6期660-663,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21073141)
关键词
唑来膦酸
咪唑
合成方法
催化剂
综述
zoledronic acid
imidazole
synthetical method
catalyst
review
