摘要
在微波辐射下,离子液体[Etpy]BF4催化邻苯二胺与取代芳醛(或直链醛)的反应,合成了12个2-取代苯并咪唑类化合物(2a^2 l),其结构经1H NMR,IR和MS表征。最佳反应条件为:邻苯二胺1 mmol,芳醛1mmol,无水乙醇6 mL,[Etpy]BF40.2 mmol,于25℃/500 W反应2 h^3 h,产率78.6%~97.7%。初步生物活性测试结果表明,部分化合物对革兰氏阴性菌和革兰氏阳性菌都具有较好的抑制活性。
Twelve benzimidazole compounds(2a^2l) were synthesized by the reaction of 1,2-phenylenediamine and substituted-aromatic aldehyde(or linear aldehyde) under microwave irradiation using ionic liquid [Etpy]BF4 as the catalyst.The structures were characterized by 1H NMR,IR and MS.The optimum reactions at 25 ℃/500 W for 2 h-3 h were as followed: 1,2-phenylenediamine was 1 mmol;aromatic aldehyde was 1 mmol;EtOH was 6 mL;[Etpy]BF4 was 0.2 mmol.The yield were 78.6%~97.7% under the optimum reactions.Preliminary biological activity test showed that some of them exhibited good bacterium activities anti-Gram positive and anti-Gram negative.
出处
《合成化学》
CAS
CSCD
北大核心
2010年第6期691-694,699,共5页
Chinese Journal of Synthetic Chemistry
基金
中央高校基本科研业务费专项资金资助项目(RL10BA05)
关键词
离子液体
邻苯二胺
醛
苯并咪唑
微波合成
抗菌活性
ionic liquid
1
2-phenylenediamine
aldehyde
benzimidazole derivative
microwave synthesis
antibacterial activity