离子液体[Etpy]BF_4催化苯并咪唑类化合物的微波合成及其抗菌活性

Catalytic Synthesis and Antibacterial Activity of Benzimidazole Compounds by Ionic Liquid [Etpy]BF_4 under Microwave Irradiation

在微波辐射下,离子液体[Etpy]BF4催化邻苯二胺与取代芳醛(或直链醛)的反应,合成了12个2-取代苯并咪唑类化合物(2a^2 l),其结构经1H NMR,IR和MS表征。最佳反应条件为:邻苯二胺1 mmol,芳醛1mmol,无水乙醇6 mL,[Etpy]BF40.2 mmol,于25℃/500 W反应2 h^3 h,产率78.6%~97.7%。初步生物活性测试结果表明,部分化合物对革兰氏阴性菌和革兰氏阳性菌都具有较好的抑制活性。

Twelve benzimidazole compounds（2a^2l） were synthesized by the reaction of 1,2-phenylenediamine and substituted-aromatic aldehyde（or linear aldehyde） under microwave irradiation using ionic liquid [Etpy]BF4 as the catalyst.The structures were characterized by 1H NMR,IR and MS.The optimum reactions at 25 ℃/500 W for 2 h-3 h were as followed： 1,2-phenylenediamine was 1 mmol;aromatic aldehyde was 1 mmol;EtOH was 6 mL;[Etpy]BF4 was 0.2 mmol.The yield were 78.6%～97.7% under the optimum reactions.Preliminary biological activity test showed that some of them exhibited good bacterium activities anti-Gram positive and anti-Gram negative.