铜绿假单胞菌医院感染38例细菌耐药率与抗菌药物应用分析

Study on 38 cases of nosocomial infection of pseudomonas aeruginosa:analysis of bacteria medicine-resistant and antibiotics application

目的:探讨铜绿假单胞菌(PA)医院感染的现状及抗菌药物治疗对策。方法:回顾性分析我院2009年5月～2009年12月发生的38例PA医院感染的临床资料。结果:本组药敏试验显示,PA对多种常用抗菌药物耐药,出现多重耐药菌株、泛耐药菌株甚至全耐药菌株,给临床治疗带来严峻挑战。抗菌药物治疗在品种选择及联合用药方面均有不合理之处。结论:铜绿假单胞菌的耐药问题较为严重,临床应根据药敏试验结果,有针对性地选用抗菌药物及2种敏感药物联合治疗,以达到合理应用抗菌药物。

Objective：To investigate the situation and countermeasure of nosocomial infection of pseudomonas aeruginosa（PA）.Methods：By a retrospective study,from May to December in 2009,38 cases of nosocomial infection of PA in our hospital were analyzed statistically.Results：Drug sensitivity tests revealed that PA was resistant to many kinds of antibiotics and it was also found multi-drug resistant strain,pan-drug resistant strain,and even per-drug resistant strain.This brought a serious challenge to the clinical treatment.There were many unreasonable aspects to antibiotic therapy in the selection of species,combination therapy.Conclusion：The problem of the pseudomonas aeruginosa resistance was serious.Therefore,in clinic therapy,it should reasonably select antibiotics and use combined treatment with two sensitive drugs according to the results of drug sensitivity tests in order to achieve the purpose of rational use of antibiotics.