期刊文献+

DNA芯片图像的自适应提取

An Automated DNA Chip Image Segmentation Method
下载PDF
导出
摘要 软件内嵌探针测试是在探针函数模板的框架内编写被测对象,并对被测对象进行面向对象软件的常规测试,在观察预期结果与实际结果是否一致的同时,还要察看探针函数输出的信息,以确定对象的状态是否正确。本论文研究的重点在于探针函数的构成、探针函数的实现及内嵌探针测试方法的应用研究,意在构筑一个基本的应用框架,提供一种实用的测试方法。 his article studies the automatic extraction of gene chip image information. In view of the difficulties in automatic processing, such as the huge number of the DNA spots, the low resolution ratio and the anomalous contour, this article proposes an automatic image division algorithm provided with high efficiency in spot localization and compact spot outline edge. Through the effective selection of structure operator, the nimble application multi-layer mathematics morphology's transformation, and the automatic binaryzation using the difference and standard deviation, this algorithm can automatically read genome image information. Through many experiments of reading genome image information, we also show that this algorithm obtain a compact image segmentation and high precision, in which its relative error with commercial software is less than 5%.
出处 《自动化博览》 2010年第11期68-68,71-73,共4页 Automation Panorama1
基金 福建省自然科学基金(2009J05153)
关键词 软件内嵌探针 探针函数 测试 DNA chip Mathematics morphology Image segmentation
  • 相关文献

参考文献7

  • 1刘长春,文孟良.生物芯片[J].分析仪器,2001(3):37-39. 被引量:2
  • 2Luis Rueda and Bidya Vidyadharan. A hill-climbing approach for automatic gridding ofcDNA microarray images[J]. IEEE Transactions on Computational Biology and Bioinformatics, 3(1),2006:72-83.
  • 3Zacharia, E.,Maroulis, D.,An Original Genetic Approach to the Fully Automatic Gridding of Microarray Images[J]. IEEE Transaction on Medical Imaging,2008, 27(6):805-813.
  • 4Antonio P.G. Damiance Jr., Liang Zhao, Andre C.P.L.F. Carvalho. A dynamical model with adaptive pixel moving for mieroarray images segmentation[J]. RealTimelmg(10) ,2004, (4): 189 195.
  • 5Glasbey C A ,Ghazal E Combinatorial Image Analysis ofDNA Microarray Features. Bioinformatics, 2003,19 (2) : 1942203.
  • 6肖松山,范世福.生物芯片图像自动识别算法研究[J].生命科学仪器,2003,1(2):40-42. 被引量:2
  • 7马驰,张红云,苗夺谦,张学东.改进的多阈值动态二值化算法[J].计算机工程,2006,32(6):203-205. 被引量:25

二级参考文献14

  • 1姚玉花,成瑜.一种身份证扫描图像的二值化方法[J].机械制造与自动化,2002,12(5):65-68. 被引量:2
  • 2[1]Fodor S P A, Read J L et al. Science, 1991, 251:767-773
  • 3[2]Shalon D, Smith S J. Genome Res, 1996, 6:639-645
  • 4[3]Strauss E. Science, 1998, 282:1406-1409
  • 5[4]Lueking A, Horn M et al. Anal Biochem, 1999, 270:103-111
  • 6[5]Woolley A T, Hadley D et al. Anal Chem, 1996, 68:4081-4086
  • 7[2]崔屹.数字图象处理技术与应用.北京:电子工业出版社,1996
  • 8Gonzalez R C,Wood R E.Digital Image Processing[M].MA Adsion Wesley,1992.
  • 9Ostu N.A Threshold Selection Method from Gray-level Histogram[J].IEEE Trans.on SMC,1979,9(2):62-66.
  • 10Abutaleb A S.Automatic Thresholding of Gray-level Pictures Using Two-dimensional Entropy[J].Computer Vision,Graphics,and Image Processing,1989,47(7):22-32.

共引文献26

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部