I型糖尿病患者植物神经病变和血压与糖尿病肾病的关系

Relationship between Autonomic Neuropathy,24h Blood Pressure and Nephropathy in Normotensive IDDM Patients

探讨Ⅰ型糖尿病患者植物神经病变和血压与糖尿病肾病的关系。方法：对４４例偶测血压正常的Ⅰ型糖尿病患者进行了心脏植物神经功能检查、２４小时动态血压监测（ＡＢＰＭ）以及尿白蛋白排泄率（ＵＡＥ）测定。结果：存在植物神经病变的Ⅰ型糖尿病患者其偶测收缩压、舒张压、ＵＡＥ均高于无植物神经病变者，且ＡＢＰＭ多项指标异常。心脏植物神经功能检查计分与ＵＡＥ及多项ＡＢＰＭ指标显著相关，但与偶测血压无相关性。结论：偶测血压正常的Ⅰ型糖尿病患者植物神经病变、２４小时血压与ＵＡＥ之间具有一定的关联。

To evaluate the relationship between autonomic neuropathy,24 h blood pressure and nephropathy in IDDM Patients. Methods: 44 normotensive IDDM patients were divided into two groups. Group 1 without cardiovascular autonomic neuropathy and group 2 with neuropathy. 24 h ambulatory blood pressure monitoring (ABPM) and urinary albumin excretion rate (UAE) were simultaneously measured. Results: IDDM patients with abnormal autonomic nerve function had higher casual SBP,DBP and UAE compared with those Who had normal autonomic nerve function. There were also many abnormal indexes of ABPM in those patients. The score of cardiovascular autonomic neuropathy had a positive correlation with UAE and many indexes of ABPM. No correlation was found between the score and casual blood pressure. conclusion: Autonomic neuropathy in IDDM patients was associated with abnormal 24 h blood pressure and elevated UAE.