对妊高征患者红细胞膜脂质过氧化和离子运输功能的观察

The Increasing Lipid Peroxidation and Transportation Function of Ions in Erythrocyte Membrane of Patients with Pregnancy-induced Hypertension

对妊高征患者红细胞膜过氧化脂质（ＬＰＯ）含量、超氧化物歧化酶（ＳＯＤ）活性、Ｎａ~＋Ｋ~＋－ＡＴＰ酶活性及膜内面 Ｃａ^(２＋)结合能力的变化进行研究。方法：检测 １９名正常孕妇， １９例妊高征患者红细胞膜 ＬＰＯ、ＳＯＤ、Ｎａ~＋－Ｋ~＋－ＡＴＰ酶活性（比色法）及膜内面Ｃａ^(２＋)结合力（原子吸收法）。结果：（１）妊高征组红细胞膜ＬＰＯ含量明显高于正常孕妇组（Ｐ＜０．００１）。（２）妊高征组红细胞膜ＳＯＤ活性明显低于正常孕妇组（Ｐ＜０．００１）。（３）妊高征组红细胞膜Ｎａ~＋－Ｋ~＋－ＡＴＰ酶活性明显低于正常孕妇组（Ｐ ＜ ０．０１）。（４）妊高征组红细胞膜内面的Ｃａ^（２＋）结合量明显低于正常孕妇组（Ｐ＜０．０１）。结论：妊高征患者红细胞膜脂质过氧化增强和抗氧化能力减低，两者间平衡破坏。红细胞膜Ｎａ~＋Ｋ~＋ＡＴＰ酶活性及膜内面Ｃａ^(２＋)结合能力的降低提示膜离子运输功能失常。

It was demonstrated that 19 patients With pregnancy-induced hypertension (PIH) had changed in lipid peroxides cont- ent (LPO), superoxide dismutase (SOD), Na^+ - K^+ - ATPase activity and calcium-binding capacity inside erythrocyte membrane. Results showed that 1. LPO content of erythrocyte membrane in patients with PIH (PIH group) was significantly higher than in normal pregnancy women (NPW group), P< 0. 001. 2. The level of SOD in PIH group was lower than that in NPW group, P< 0. 001. 3. Na^+ - K^+ - ATPase activity in PIH group was also decreased, P< 0. 01. 4. The calcium-bind- ing capacity inside erythrocyte membrane in PIH group was remarkably lower than that in NPW group, P< 0. 01 .The results indicated that lipid peroxidation in patients with PIH increased, and the capability of antioxidation decreased, the balance relationship was disturbed. The decrease of Na^+ - K^+ - ATPase activity and calcium-binding capacity inside erythrocyte membrane indicated that membrane transportation function of ion was at imbalance. The above indexes may Play an important role in the development of PIH.