环境与家系因素对单纯性肥胖儿童血脂谱水平的影响研究

Study on the effection of environment and genealoty about lipids with simple obesity children

【目的】研究单纯性肥胖儿童血脂谱水平的影响因素,为高危儿童进行早期血脂筛查及早期干预提供一定的临床依据。【方法】将随机抽取的88例单纯性肥胖儿童及84例正常儿童进行病例对照研究,对两组分别进行体格测量、相关病史、生活方式、饮食情况及家族情况问询,并通过专业的膳食分析软件对饮食情况进行处理分析,另外抽取空腹静脉血作甘油三酯(triglyceride,TG)、胆固醇(total cholesterol,TC)、高密度脂蛋白(high-density lipoprotein cholester-ol,HDL-C)、低密度脂蛋白(low-densitylipoprotein cholesterol,LDL-C)、载脂蛋白A(apolipoprotein A,ApoA)、载脂蛋白B(apolipoprotein B,ApoB)检测,从而分析单纯性肥胖儿童血脂谱水平的影响因素。【结果】实验组儿童的血TG、TC、LDL-C、ApoA水平高于对照组儿童,血HDL-C低于对照儿童,且差异有统计学意义(P<0.01),实验组血脂异常率、高TG率及低HDL-C率与对照组相比差异也有统计学意义(P<0.05)。随着肥胖程度的升高,单纯性肥胖儿童血脂的异常率随之升高,呈线性趋势(χ2=4.064,P<0.01)。油炸食物、高饱和脂肪酸摄入、高胆固醇摄入、高锌摄入、父母高血脂、心血管家族史是单纯性肥胖儿童血脂水平的危害因素(P<0.05),运动则是保护性因素(P<0.01)。【结论】儿童的肥胖程度、不良饮食方式、父母高血脂、心血管家族史及运动是单纯性肥胖儿童血脂的影响因素。早期干预这些影响因素是临床控制单纯性肥胖儿童血脂异常的有效途径。

【Objective】 To study the influencing factors about lipids with simple obesity children,and to provide clinic accordance with high risk child do prophase lipid screening and prophase interference.【Methods】 88 cases of sim-ple obesity children and 84 cases of normal children were selected by random sampling to proceed case control study.Both the two groups were had physique measurement,answer the questionnaire about relevant case history,life style,diet condi-tion,family information.Use professional analyses software to handling the diet condition.At equal pace,triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A（apoA） and apolipoprotein B（apoB） were determined with the 12~14 h fasting blood.Colligation above,to study.【Results】 Level of TG,TC,LDL-C,ApoA with experimental group were higher than those of control group and level of HDL-C was lower.The difference had statistical significance（P 0.01）.The difference of dyslipidemia rate,high TG rate and low HDL-C rate between two groups was also statistically significant（P0.05）.Along with the set up of degree of obesity,the rate of dyslipidemia was higher and presentation linearity tendency（χ2= 4.064,P 0.01）.Frying food,high intake of saturated fatty acid,cholesterol,zinc,parents have high blood lipids,family history of cardiovascular disease were hazard factors with simple obesity children（P0.05）,exercise was protect factor with simple obesity children（P0.01）.【Conclusions】 Degree of obesity,bad diet manner,parents have high blood lipids,family history of cardio-vascular disease and exercise were influential factors with simple obesity children.The early phase interventions which ai-ming at those influential factors could be effective to control dyslipidemia of simple obesity children.