食品与机体中的移动通讯网络

Wireless Communication Networks between Food and Human Body

在总结近年来有关食品胃肠黏膜信号通路研究的基础上,根据现代免疫学的研究成果,提出机体中存在着移动细胞之间的通讯网络的假说,该假说认为:细胞因子网络实际上就是移动通讯网络的信号传递系统;机体中的移动细胞可以依赖细胞因子,通过自分泌、旁分泌进行局部通讯;通过内分泌进行远距离全局性通讯;通过和固定细胞之间的信号交流和胃肠道黏膜、神经内分泌系统进行高密度的通讯联系,从而形成一个"无线"和"有线"之间相互协调的通讯网络;在这个通讯网络中,细胞通过受体及其信号传递、级联放大系统接受并通过基因表达与调控定量放大这些细胞信号,从而发挥生命活动;而细胞因子和趋化因子等信号分子则通过循环系统在固定和移动细胞之间传递信号,分子之间互不干涉,在极低的浓度下通过相应的细胞发挥通讯媒体的作用。作者通过研究发现:功能性食品正是通过改变这个复杂的通讯网络发挥其生物功能。这一理论和研究方法的建立将有可能从根本上改变功能性食品如何发挥生物功能的评价方法和标准。

A new hypothesis of cellular wireless communication networks was proposed on the basis of current research achievements in the field of immunology,which were summarized from gastrointestinal mucous receptor pathways of foods.In this hypothesis,cytokine network was a signal transduction system during cell communications.The cells especially for leukocytes can communicate with each other in networks by a manner of paracrine or autocrine.In addition,the cells can also execute long-distance whole communication through the autocrine mode.A coordinated communication network between wireless and wire communications was established through cellular communication between gastrointestinal mucous and neuroendocrine system.In this communication network,cells accepted gene expression and quantitative regulation of cellular signal amplification through receptors,signal transduction and cascade system.However,the cytokine and chemokine can accomplish the signal transduction through circulatory system among cells without mutual interference even at the condition of low concentration.Functional foods can change the complex communication networks to realize their biological functions.Therefore,the establishment of this theory and research method will have the potential to alter functional foods.