移植物抗宿主病与异种移植研究综述

GRAFT VERSUS HOST DISEASE AND XENOTRANSPLANTATION

目的对移植物抗宿主病的发生条件、发病机制、疾病特点及检测方法的研究进行简要综述。方法对近年来国内外有关文献进行检索，总结。结果移植物抗宿主病的发生需要一定的条件，细胞及体液免疫均参与该病的发病过程，根据其特点可用相应的监测方法进行诊断和分级。结论作为移植物与宿主相互作用的一种形式，移植物抗宿主病对宿主可产生严重危害；它在异种移植中也可出现，且因能用于异种移植免疫、肿瘤免疫等研究，正逐渐受到重视。

Objective The pathogenesis, mechanism, manifestation and diagnosis of graft versus host disease(GVHD) are reviewed in this article.Methods The relevant articles in recent public magzines were reviewed and summerized.Results It was indicated that GVHD occurred in the conditioned recipients in animal experiments and clinical transplantations. Humoral and cellular factors were involved in GVHD, which could be diagnosed and classified according to their characteristics. Conclusion As a kind of interactions between the host and donor, GVHD are severely harmful to the host. It may also occur in xenotransplantation, where GVHD can be utilized in the studies on transplant immunology, oncology etc. Xenogeneic GVHD is receiving more and more attentions.