刺激下肢不同穴位在双侧感觉皮质引发的激活效应差异

Discrepancy in effects of stimulating different acupoints of unilateral lower extremities on activation responses in bilateral primary somatosensory cortices

目的:观察刺激人体右侧下肢不同穴位在双侧初级感觉皮质的激活效应差异。方法:共10例受试者接受功能性磁共振成像。采用3.0T Siemens MAGNETOM Trio磁共振成像系统采集全脑T2*像。穴位刺激采用组块方式,共有4个穴位受刺激。以SPM5软件包分析数据,采用贝叶斯推断方法,识别相对于基线水平,穴位刺激在双侧初级感觉皮质引发的激活效应信号。使用LI toolbox计算偏侧化指数。结果:对于每一穴位,均有80%受试者LI值为正,20%受试者LI值为负。各穴位LI值之间未发现显著性差异。不同穴位中,以足三里穴刺激所得LI值均数值最低,以三阴交穴刺激所得LI值变异系数最大。结论:刺激一侧下肢穴位可以对双侧初级感觉皮质发挥调节效应,且不同穴位具有不同的调节效应。

Objective：To investigate the discrepancy in effects of stimulating different acupoints of right lower extremities on activation responses in bilateral primary somatosensory cortices.Method：Ten male healthy subjects received functional MRI examination with 3.0T Siemens Magnetron Trio system.A block-designed method was applied.Four acupoints were stimulated respectively.Data were analyzed with SPM5 software package with 1st level Bayesian inference.Lateralization indices（LI） were acquired with LI toolbox.Result：For each acupoint 80% subjects had positive LI values.No statistically difference in LI values was found among four acupoints,whereas the mean of LI value acquired from stimulating Zusanli acupoint（ST36） was the lowest and the coefficient variation of LI value acquired from stimulating Sanyinjiao acupoint（SP6） was the highest among all four acupoints.Conclusion：Status of bilateral primary somatosensory cortices could be modulated from stimulating the unilateral acupoints located on the lower extremity,with different acupoints showing different features of modulating effects.