摘要
目的评价吸入一氧化氮（ＮＯ）对再灌注兔肺气体交换改善的效果。方法４０只健康新西兰大白兔随机分成４组，每组１０只。Ⅰ组未缺血组；Ⅱ组未缺血＋吸入ＮＯ组；Ⅲ组缺血再灌注组；Ⅳ组缺血再灌注＋吸入ＮＯ组。Ⅱ、Ⅳ组吸入ＮＯ５０×１０－６，再灌注２４０ｍｉｎ连续动态观察ＰａＯ２、ＰａＣＯ２、Ａ－ａＤＯ２、Ｑｓ／Ｑｔ、高铁血红蛋白。结果（１）吸入ＮＯ不影响正常兔肺气体交换功能；（２）再灌注时吸入ＮＯ后ＰａＯ２上升，ＰａＣＯ２、Ａ－ａＤＯ２、Ｑｓ／Ｑｔ下降。（３）吸入ＮＯ对高铁血红蛋白的升高无明显影响。结论吸入ＮＯ能明显改善再灌注肺早期气体交换功能。
Objective\ To evaluate the effect of pulmonary gas exchange by inhaled nitric oxide(INO) on ischemia reperfusion(I/R) lung in rabbit model.\ Methods\ Forty Newzealand rabbits were divided into four groups: groupⅠ normal control; group Ⅱ no I/R with INO; group Ⅲ I/R; group Ⅳ I/R with INO. \ PaO 2, PaCO 2, A aDO 2, Qs/Qt and methemoglobin were continuously observed quantitatively.\ Results\ (1)INO unaffected the gas exchange of the normal lung.\ (2)INO provided at the start of reperfusion significantly improved PaO 2 and decreased PaCO 2, A aDO 2, Qs/Qt.\ (3)No significant effect of INO on methemoglobin.\ Conclusion\ INO can significantly ameliorate the early gas exchange of reperfusion lung.
出处
《福建医科大学学报》
1999年第2期144-148,共5页
Journal of Fujian Medical University
